It is a condition of toxemia due to
absorption of soluble toxin from the wound contaminated with
clostridium tetani.Causative
organism:
Clostridium tetani is an anerobic gram +ve
bacteria with a terminal spore giving a characteristic drum
stick appearance. This is mainly found in manure and soil.
It mainly releases mainly two types of
exotoxins
1. Tetanospasmin: it is a neurotoxin acts
on motor end plates
2. Tetanolysin: it is a oxygen labile
haemolytic toxin
Mode of entry:
1. usually through a penetrating wound
2. dirty abrasions
3. chronic ulcers like boils, paronychia,
dental extractions
4. subcutaneous injections of irritant
drugs
5. contaminated umbilical cord of a
neonate
6. post abortal and post puerperal
7. post operative tetanus
Incubation period:
3days to 3weeks on an average 7days
The time interval between 1st symptom and
1st reflex spasm is called period of onset. The less the
onset period the condition is more fatal.
Pathology:
The soluble toxin is absorbed from the
site of infection.
The spores germinate in the anaerobic
condition which is contributed by necrosis and
devitalisation of site of injury, Calcium ions derived from
soil or hemorrhage.
The toxin reaches the central nervous
system either through nervous route, blood stream or by
lymphatic channel.
Then it gets fixed to the anterior horn
cells of the nerve and causes hyperexitability of motor
neurons and inhibits cholinesterase leading to reflex spasms
Clinical features:
1. Trismus (locked jaw)
2. Stiffness of muscles of head, neck,
back, abdomen.
3. Risus sardonicus
4. Opisthotonous (bow like bending) of the
body. Some times psoas and abdominal muscles may rupture
5. Dysphagia due to spasm of deglutition
muscles
6. At early stages the spasms are
conditional & later becomes unconditional
7. Constitutional symptoms like fever,
cyanosis are present
8. High temperature (fever) of 38C
(100.4F), or above
9. Rapid heartbeat (tachycardia)
10. Sore throat
11. Sweating
12. Headache
13. Extreme sensitivity to touch
Main Causes of death
1. Pulmonary infections mainly
bronchopneumonia
2. Aspiration of pharyngeal contents
leading to Suffocation (asphyxia)
3. Laryngeal spasm
4. Pulmonary embolism due to dislodgement
of emboli
5. Anemia & exhaustion due to repeated
convulsions
6. Hyperpyrexia
7. Compression fracture of thoracic
vertebrae
8. Blood poisoning (septicaemia)
9. Heart attack
10. Kidney failure
Prophylaxis:
1. to give active immunization of alum
precipitated tetanus toxoid Im along with diphtheria and
pertusis (DPT) In the child hood for every newborn
2. proper surgical wound care is necessary
3. isolation of patient in a quiet, dark
room
Homeopathic approach:
Nux vomica:
1.It has tetanic convulsions with
opisthotonos, distortion of eyes and face, with dyspnoea
excited by any external impression.
2. convulsion of muscles renewed by the
slightest external impression,
3. risus sardonicus
4. respiratory spasm
5. blue cyanosed face
6. clear mind..
Hydrocyanic acid:
1. It produces a persistent tonic spasm
from its direct action on the spinal cord. It shows itself
in the muscles of the face, jaws and back.
2. There is trismus or locked jaw, risus
sardonicus and impeded respiration, with lividity and
frothing at the mouth; the rigidity is firm
3. The body is bent backwards
4. The attack is sudden
5. There is less reflex excitability.
6. Painful stiffness and stretching of the
limbs.
7. The lips are drawn back showing the
teeth and the jaws are locked.
Cicuta virosa:
1. Sudden rigidity and jerkings followed
by prostration.
2. Great oppression of breathing.
3. Locked jaw.
4. Opisthotonos renewed by touch.
5. There are oesophageal spasms
6. A marked symptom is fixed eyes staring
at one point.
Physostigma:
1. The sensory nerves are irritable.
2. There are tetanic spasms stiffness of
spine and legs
3. Alternate dilation and contraction of
the pupils.
Stramonium:
1. Tetanic convulsions
2. Spasms of glottis and chest worse from
light or touch.
Aconite:
1. Tetanus, with fever
2. Numbness and tingling from exposure to
cold
3. The face changes color.
4. Great Fear of death
Cuprum:
1. Pale face
2. Jerking
3. Opisthotonos
4. Patient loses consciousness with each
spasm.
5. Coldness of extremities.
Hypericum:
1. Trismus from injury to nerves.
2. Useful in spinal injuries
Belladonna:
1. Tetanus of infants.
2. Stiffness of jaws.
Other remedies:
1. Magnesia phosphorica, Carbolic acid,.
Phenol, Passiflora, Ignatia